Short Communication Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain
نویسندگان
چکیده
Jens Lykkesfeldt*, Gilberto Perez Trueba, Henrik E. Poulsen and Stephan Christen Section of Biomedicine, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, 9 Ridebanevej, DK-1870 Frederiksberg C, Denmark Department of Clinical Pharmacology Q, Copenhagen University Hospital, 20 Blegdamsvej, DK-2200, Kbh K, Copenhagen, Denmark Institute of Infectious Diseases, University of Berne, Friedbühlstrasse 51, CH-3010 Berne, Switzerland
منابع مشابه
Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain.
Neonates are particularly susceptible to malnutrition due to their limited reserves of micronutrients and their rapid growth. In the present study, we examined the effect of vitamin C deficiency on markers of oxidative stress in plasma, liver and brain of weanling guinea pigs. Vitamin C deficiency caused rapid and significant depletion of ascorbate (P < 0.001), tocopherols (P < 0.001) and gluta...
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